Pseudo-UTP

Pseudo-UTP

Author: ApexBio

purity:

≥ 97% by AX-HPLC

shortsummary:

A modified nucleoside-5’-O-triphosphate, commonly used for drugable mRNA synthesis

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Synonyms:

Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil

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Formula:

C9H15N2O15P3 (free acid)

M.Wt:

484.1 (free acid)

Chemical Name:

lithium (5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate

SMILES:

O=C(NC=C1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+]

Storage:

Store at -20°C or below

Physical Appearance:

Solution

DeliveryTime:

In stock

Cholesterol

ShippingType:

Dry ice

description:

Pseudo-UTP, also known as pseudouridine-5’-O-triphosphate, is one of the most commonly used modified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both gene and vaccination therapy. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. Thus, pseudo-UTP could be used to develop drugable mRNAs with improved properties, by replacing the standard bases by modified ones.

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 7147 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.